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About INFUSE® Bone Graft (rhBMP-2/ACS)

Nothing is as reliable for placing implants as a patient's own bone.
INFUSE® Bone Graft regenerates vital, vascular de novo bone for dental implant placement.
It has been approved by the U.S. Food and Drug Administration for use as an alternative to
autograft in sinus augmentation and localized alveolar ridge augmentation for defects
associated with extraction sockets. INFUSE® Bone Graft consists of recombinant human
Bone Morphogenetic Protein-2 (rhBMP-2) delivered on an Absorbable Collagen Sponge (ACS).

INFUSE® Bone Graft promotes natural bone growth to give you long-term implant success.

How INFUSE® Bone Graft works

The active component of INFUSE® Bone Graft - rhBMP-2- is a recombinantly-produced form
of a signaling protein naturally occurring in the human body. This particular protein has been
proven to be an important element in the body’s own bone-healing cascade, inducing cells
to form biologic bone via osteoinduction.

The rhBMP-2 mechanism of action initiates the body’s own bone-healing cascade:

  • INFUSE® Bone Graft is implanted in the surgical site.
  • Chemotaxis, or attraction of mesenchymal stem cells to the site, occurs.
  • Mesenchymal stem cells proliferate, or increase rapidly in number, at the site due to the
    presence of rhBMP-2, supported by increased angiogenesis at the site.
  • Mesenchymal stem cells differentiate, or begin to change from stem cells to osteoblast cells,
    due to the binding of rhBMP-2 molecules to cell-surface receptors on the stem cells.
  • Bone tissue begins to form around the osteoblasts, and it goes on to mineralize and mature
    as normal anatomic bone does.
  • Mechanical forces on the mineralized bone tissue cause the new bone created in the
    rhBMP-2 implantation site to continuously remodel, just as normal physiologic bone
    would be expected to respond.